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Tylenol has several proposed mechanisms but importantly it is metabolized by the liver. Even so most preparations with hydrocodone are in combination with acetaminophen. The Dangers Of Mixing Aspirin And Acetaminophen Tylenol Youmemindbody Acetaminophen and aspirin is a combination medicine used to treat minor arthritis pain back pain and muscle aches. Can you take aspirin and tylenol together . Tylenol is a brand name for acetaminophen a type of pain reliever and fever reducer. It works by reducing substances in the body that cause pain fever and inflammation. However longterm mixing of acetaminophen the ingredient in Tylenol and aspirin can result in renal kidney damage. Taking aspirin for heart health is a decision you should make with your doctor. They can help you to understand that acetaminophen the active ingredient in TYLENOL gives you strong pain relief and wont interfere with your aspirin heart therapy the way ibuprofen can. Aspirin inhibits cyclooxygenase 1 and