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It is possible even with home treatment to get rid of a stye overnight or within 1 to 2 days. To relieve the pain take painkillers such as paracetamol or ibuprofen. Why You Should Never Pop A Stye Hold it against your eye for 5 to 10 minutes. Best medication for a stye . Treatment of the underlying cause of the sty is also important to prevent recurrence. Topical antibiotic creams and gels are less effective but may be prescribed in some situations. To help drain the styes pus and ease the pain take a folded clean cloth and use it as a compress. However if after 48 hours of home treatments the stye does not respond medical treatments may be considered according to the Cleveland Clinic. Doxycycline doesnt work like most antibiotics work by inhibiting the growth of microorganisms because the bacteria that causes a stye is naturally resistant to staphylococcus aureus which is. A doctor might prescribe doxycycline for a persistent stye or recurring styes. Over-the-cou...